Mesenchymal Stem Cell-derived Extracellular Vesicles for Renal Repair

Title:Mesenchymal Stem Cell-derived Extracellular Vesicles for Renal Repair

Volume: 17 Issue: 1

Author(s): Arash Aghajani Nargesi, Lilach O. Lerman and Alfonso Eirin*

Affiliation:

• Division of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905,United States

Keywords: Exosomes, extracellular vesicles, kidney, mesenchymal stem cells, microRNA, microvesicles.

Abstract: Introduction: Transplantation of autologous mesenchymal stem cells (MSCs) has been shown to attenuate renal injury and dysfunction in several animal models, and its efficacy is currently being tested in clinical trials for patients with renal disease. Accumulating evidence indicates that MSCs release extracellular vesicles (EVs) that deliver genes, microRNAs and proteins to recipient cells, acting as mediators of MSC paracrine actions. In this context, it is critical to characterize the MSC-derived EV cargo to elucidate their potential contribution to renal repair. In recent years, researchers have performed high-throughput sequencing and proteomic analysis to detect and identify genes, microRNAs, and proteins enriched in MSC-derived EVs.

Cite this article as:

Nargesi Aghajani Arash, Lerman O. Lilach and Eirin Alfonso*, Mesenchymal Stem Cell-derived Extracellular Vesicles for Renal Repair, Current Gene Therapy 2017; 17 (1) . https://dx.doi.org/10.2174/1566523217666170412110724