Perspectives of Gene Therapies in Autosomal Dominant Polycystic Kidney Disease

Title:Perspectives of Gene Therapies in Autosomal Dominant Polycystic Kidney Disease

Volume: 17 Issue: 1

Author(s): Yuchen Xu, Ao Li, Guanqing Wu*Chaozhao Liang*

Affiliation:

• Anhui Province PKD Center, Institute/Department of Urology, The First Affiliated Hospital, Anhui Medical University, Hefei, 230022,China

• Institute/Department of Urology, The Anhui Province PKD Center, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, 230022,China

Keywords: Aberrant signaling pathways, ADPKD, causative genes, gene therapy, kidney disease, translational medicine.

Abstract: Background: Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease in the clinic. The predominant clinical manifestation is bilateral and progressive cysts formation in the kidneys, impairs normal renal parenchyma, and ultimately leads to endstage renal disease (ESRD). ADPKD is a heterogenic disease which is resulted from the mutations of PKD1 or PKD2 genes which encode polycystin-1 (PC1) and -2 (PC2), thereby multiple cell signaling pathways are involved.

Cite this article as:

Xu Yuchen , Li Ao, Wu Guanqing*, Liang Chaozhao*, Perspectives of Gene Therapies in Autosomal Dominant Polycystic Kidney Disease, Current Gene Therapy 2017; 17 (1) . https://dx.doi.org/10.2174/1566523217666170510152808