MAPK抑制剂与免疫疗法在结肠癌治疗中的最新进展

Title:Emerging Insight into MAPK Inhibitors and Immunotherapy in Colorectal Cancer

Volume: 24 Issue: 14

关键词: 促分裂原活化蛋白激酶，结肠癌，免疫性，免疫抑制剂，免疫疗法，细胞外受体活化激酶，p38丝裂原活化蛋白激酶

摘要: Our understanding of the genetic and non-genetic molecular alterations associated with colorectal cancer (CRC) progression and therapy resistance has markedly expanded in the recent years. In addition to their effects on tumor biology, targeted therapies can have effects on host immune responses. However, the mechanisms by which immune cells organize tumor microenvironments to regulate T-cell activity need to be comprehensively defined. There is good evidence in the literature that alterations in different members of the MAPK superfamily (mainly ERKs and p38 MAPKs) modify the inflammatory response and antitumor immunity, enhancing metastatic features of the tumors. In addition, a plethora of alterations that emerge at relapse often converge on the activation of MAPKs, particularly, ERKs, which act in concert with other oncogenic signals to modulate cellular homeostasis and clonal evolution during targeted therapies. Herein, we discuss how this knowledge can be translated into drug development strategies aimed at increasing tumor antigenicity and antitumor immune responses. Insights from these studies could provide a framework for considering additional combinations of targeted therapies and immunotherapies for the treatment of CRC.

Cite this article as:

Emerging Insight into MAPK Inhibitors and Immunotherapy in Colorectal Cancer, Current Medicinal Chemistry 2017; 24 (14) . https://dx.doi.org/10.2174/0929867324666170227114356