Abstract
Background: The Carrier linked prodrug as per literature is known to be a pharmacologically inactive chemical derivative and could be used to change the physicochemical properties of compounds. Codrugs is a type of carrier linked prodrug, and consist of two usually synergistic drugs or moieties attached to each other.
Objective: synthesis of codrug consists of two pharmacologically active compounds coupled together where one drug is the carrier for the other and vice versa. Result: It is a very beneficial area of research and its admittance in human therapy has given successful results clinically as well as therapeutically. Conclusion: The emphasis is carried on Benorylate, the Codrug of aspirin and paracetamol for improved anti-inflammatory and analgesic activity. The article also takes a review of the various applications of Codrugs and the development in this field during the last few decades.Keywords: Prodrugs, codrugs, carrier linked prodrugs, spacer, benorylate.
Graphical Abstract
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