C. elegans as Model for Drug Discovery

Title:C. elegans as Model for Drug Discovery

Volume: 17 Issue: 18

Author(s): Maria Carretero, Gregory M. Solis and Michael Petrascheck*

Affiliation:

• Department of Chemical Physiology, Department of Molecular and Experimental Medicine, Department of Molecular and Cellular Neuroscience, The Scripps Research Institute, La Jolla, CA,,United States

Keywords: C. elegans, Cancer biology, HTS, Nematodes, Vertebrate vascular endothelial growth factors, Drug discovery.

Abstract: Small molecule screens using C. elegans as a model are becoming increasingly popular as the number of high-throughput methodologies has steadily increased over the years. Here we focus on the biology that underlies this increased popularity and outline the reasons that make C. elegans an attractive model for drug discovery. We discuss successful C. elegans based drug discovery projects in the literature and future challenges ahead.

Cite this article as:

Carretero Maria, Solis M. Gregory and Petrascheck Michael*, C. elegans as Model for Drug Discovery, Current Topics in Medicinal Chemistry 2017; 17 (18) . https://dx.doi.org/10.2174/1568026617666170131114401