Abstract
Resveratrol (3, 5, 4’-trihydroxy-trans-stilbene, RVT), a stilbenoid, polyphenol phytochemical present in berries, grape, peanuts and wine. It has been suggested as a major contributor to “French Paradox” that reduces the mortality from coronary heart disease (CHD) by consuming RVT in red wine even in some of French population with a high-fat intake. With extensive research, it has been found that RVT is a versatile and pleiotropic agent, it not only possesses cardiovascular-protective benefits by its powerful antioxidant capacity, anti-inflammatory, regulating metabolism and anti-aging effects, but also has strong anti-tumor activities through inhibiting tumor cell proliferation, inducing cell apoptosis, promoting tumor cell differentiation, preventing tumor invasion and metastasis, and further moderating the host immune system to kill tumor cells. This review will focus on RVT’s anti-tumor activity and tumor prevention potential including: the anti-tumor spectrum in vitro and in vivo; molecular targets and signal pathways involving RVT anti-tumor mechanisms; evidences from clinical trial for its bioavailability, dosage, toxicity and benefit in humans; and its prospective including its analog, deviations, and combinative chemotherapy.
Keywords: Anti-cancer activity, cancer therapy, mechanisms, paradox, resveratrol.
Anti-Cancer Agents in Medicinal Chemistry
Title:From French Paradox to Cancer Treatment: Anti-cancer Activities and Mechanisms of Resveratrol
Volume: 14 Issue: 6
Author(s): Xuan Yang, Xun Li and Jinyu Ren
Affiliation:
Keywords: Anti-cancer activity, cancer therapy, mechanisms, paradox, resveratrol.
Abstract: Resveratrol (3, 5, 4’-trihydroxy-trans-stilbene, RVT), a stilbenoid, polyphenol phytochemical present in berries, grape, peanuts and wine. It has been suggested as a major contributor to “French Paradox” that reduces the mortality from coronary heart disease (CHD) by consuming RVT in red wine even in some of French population with a high-fat intake. With extensive research, it has been found that RVT is a versatile and pleiotropic agent, it not only possesses cardiovascular-protective benefits by its powerful antioxidant capacity, anti-inflammatory, regulating metabolism and anti-aging effects, but also has strong anti-tumor activities through inhibiting tumor cell proliferation, inducing cell apoptosis, promoting tumor cell differentiation, preventing tumor invasion and metastasis, and further moderating the host immune system to kill tumor cells. This review will focus on RVT’s anti-tumor activity and tumor prevention potential including: the anti-tumor spectrum in vitro and in vivo; molecular targets and signal pathways involving RVT anti-tumor mechanisms; evidences from clinical trial for its bioavailability, dosage, toxicity and benefit in humans; and its prospective including its analog, deviations, and combinative chemotherapy.
Export Options
About this article
Cite this article as:
Yang Xuan, Li Xun and Ren Jinyu, From French Paradox to Cancer Treatment: Anti-cancer Activities and Mechanisms of Resveratrol, Anti-Cancer Agents in Medicinal Chemistry 2014; 14 (6) . https://dx.doi.org/10.2174/1871520614666140521121722
DOI https://dx.doi.org/10.2174/1871520614666140521121722 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Comparison between Atorvastatin and Rosuvastatin on Secondary Percutaneous Coronary Intervention Rate and the Risk Factors in Patients with Coronary Heart Disease
Current Drug Metabolism Therapeutic Targets for Management of Periodontitis and Diabetes
Current Pharmaceutical Design Ivabradine: The Hope for a Good Treatment of Ischemic Heart Disease
Current Medicinal Chemistry Prevention of Endothelial Dysfunction and Cardiovascular Disease by n-3 Fatty Acids-Inhibiting Action on Oxidative Stress and Inflammation
Current Pharmaceutical Design Editorial [Hot Topic: New Drug Targets for the Treatment of Asthma (Guest Editor: D. Knight)]
Current Drug Targets The Metabolomic Strategy in Tuberculosis Therapy
Combinatorial Chemistry & High Throughput Screening Editorial (Thematic Issue: Alcoholic Liver Disease: From Bench to Bedside)
Reviews on Recent Clinical Trials Physiological Significance and Therapeutic Potential of Adrenomedullin in Pulmonary Hypertension
Cardiovascular & Hematological Disorders-Drug Targets Platelet in Progression of Atherosclerosis: A Potential Target in Diabetic Patients
Current Diabetes Reviews Low Lymphocyte Count and Cardiovascular Diseases
Current Medicinal Chemistry Use of Chou’s 5-steps Rule to Study the Effect of Cereal Dietary Protein on Liver and Coronary Heart Disease Prevention
Current Nutrition & Food Science Applying Knowledge of Enzyme Biochemistry to the Prediction of Functional Sites for Aiding Drug Discovery
Current Topics in Medicinal Chemistry Cardiovascular Involvement in Pediatric Systemic Autoimmune Diseases: The Emerging Role of Noninvasive Cardiovascular Imaging
Inflammation & Allergy - Drug Targets (Discontinued) How Effective are the Lipid Modifying Medicines at Preventing Coronary Heart Disease in Patients with the Metabolic Syndrome?
Vascular Disease Prevention (Discontinued) Pathophysiology of Arterial Hypertension: Insights from Pediatric Studies
Current Pediatric Reviews The Innovations in Pulmonary Hypertension Pathophysiology and Treatment: What are our Options!
Current Respiratory Medicine Reviews Apolipoprotein(a) Antisense Oligonucleotides: A New Treatment Option for Lowering Elevated Lipoprotein(a)?
Current Pharmaceutical Design A Critical Review of Bioactive Food Components, and of their Functional Mechanisms, Biological Effects and Health Outcomes
Current Pharmaceutical Design Body Composition and -174G/C Interleukin-6 Promoter Gene Polymorphism: Association with Progression of Insulin Resistance in Normal Weight Obese Syndrome
Current Pharmaceutical Design Inflammatory Markers in Coronary Artery Disease: Pathophysiological Mechanisms, Prognostic and Therapeutic Implications
Current Cardiology Reviews