摘要
目的:阿尔茨海默病(AD)高等教育与死亡率增加之间的联系是有争议的。此外,教育预测所有痴呆亚型的生存情况尚不清楚。与没有痴呆症的参与者相比,我们评估了痴呆症患者的死亡率和死亡原因。 方法:参与者来自西班牙中部的神经系统疾病,这是一项基于人群的老年人队列研究。我们比较269人与痴呆患者2944人没有痴呆症。我们进行Cox回归模型,以预测依赖于协变量调整教育程度的死亡风险。死亡原因是从国家人口登记册获得的。 结果:中位随访5.4年,有400人死亡(171例伴痴呆,229例无痴呆)。在痴呆症患者中,受过高等教育的人群死亡风险高于受教育程度较低的人群;调整后的风险比(HRa)为1.40(95%置信区间[CI],1.01〜1.94)。当分析仅限于AD患者时,HRa升高至1.51(95%CI = 1.01-2.24)。相比之下,教育程度与参与者没有痴呆症死亡率增加无关(HRa = 0.92,95%CI = 0.71-1.20,p = 0.55),而教育不影响QD死亡率。 结论:我们的研究结果表明,高教育程度与痴呆症患者死亡风险增加有关。这种观察意味着,在任何临床严重程度的高等教育患者中,神经病理学更为先进,导致这些患者在诊断后更早死亡。
关键词: 教育,痴呆,阿尔茨海默病,认知储备,死亡率,基于人群的研究。
Current Alzheimer Research
Title:Is Educational Attainment Associated with Increased Risk of Mortality in People with Dementia? A Population-based Study
Volume: 14 Issue: 5
关键词: 教育,痴呆,阿尔茨海默病,认知储备,死亡率,基于人群的研究。
摘要: Objective: The association between higher education and increased mortality in Alzheimer's disease (AD) is controversial. Further it is unknown whether education predicts survival in all dementia subtypes. We assessed mortality rates and death causes of persons with dementia compared to participants without dementia.
Methods: Participants derive from the Neurological Disorders in Central Spain, a prospective population- based cohort study of older adults. We compared 269 persons with dementia to 2944 participants without dementia. We carried out Cox regression models to predict the risk of mortality dependent on the educational attainment adjusting for covariates. Reasons of death were obtained from the National Population Register. Results: During a median follow-up of 5.4 years, 400 individuals died (171 with dementia, 229 without dementia). Among the participants with dementia, those with higher educational attainment had an increased risk of death than those with lower education; the adjusted hazard ratio (HRa) was 1.40 (95% confidence interval [CI], 1.01 to 1.94). When the analysis was restricted to patients with AD the HRa increased to 1.51 (95% CI = 1.01-2.24). By contrast, educational attainment was not associated with increased mortality among participants without dementia (HRa = 0.92, 95% CI = 0.71-1.20, p = 0.55), whereas education did not influence mortality in QD. Conclusion: Our findings suggest that high educational attainment is associated with increased mortality risk in people with dementia. This observation implies that neuropathology is more advanced in patients with higher education at any level of clinical severity, leading these individuals to an earlier death after diagnosis.Export Options
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Cite this article as:
Is Educational Attainment Associated with Increased Risk of Mortality in People with Dementia? A Population-based Study, Current Alzheimer Research 2017; 14 (5) . https://dx.doi.org/10.2174/1567205013666161201200209
DOI https://dx.doi.org/10.2174/1567205013666161201200209 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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