β-Sheet Breakers for Alzheimers Disease Therapy

Title: β-Sheet Breakers for Alzheimers Disease Therapy

Volume: 5 Issue: 6

Author(s): Bieler S. and Soto C.

Affiliation:

Keywords: alzheimer disease, amyloid, therapy

Abstract: A growing wealth of evidence indicates that the key pathological event in Alzheimers disease is the conversion of the normal soluble amyloid-β peptide into β-sheet-rich oligomeric structures which have a neurotoxic activity and ability to form insoluble amyloid deposits that accumulate in the brain. b-sheet breakers constitute a new class of drugs that are designed to specifically bind amyloid-β peptide and block and / or reverse this abnormal conformational change. In this article we review this approach, describe diverse compounds reported to have this activity and summarize the data supporting the view that b-sheet breakers could be serious candidates to combat this devastating disease.

Cite this article as:

S. Bieler and C. Soto, β-Sheet Breakers for Alzheimers Disease Therapy, Current Drug Targets 2004; 5 (6) . https://dx.doi.org/10.2174/1389450043345290