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ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

Neuroprotection & Mechanism of Ethanol in Stroke and Traumatic Brain Injury Therapy: New Prospects for an Ancient Drug

Author(s): Karam Asmaro, Paul Fu and Yuchuan Ding

Volume 14, Issue 1, 2013

Page: [74 - 80] Pages: 7

DOI: 10.2174/1389450111314010008

Price: $65

Abstract

Effective efforts to screen for agents that protect against the devastating effects of stroke have not produced viable results thus far. As a result this article reviews the possible role of ethanol as a neuroprotective agent in stroke and traumatic brain injury (TBI). Previous studies have associated ethanol consumption with a decreased risk of ischemic stroke, suggesting a neuroprotective mechanism. The translation of this clinical knowledge into basic science research with the goal of new therapy for acute stroke patients remains in its initial stages. In a recent study involving rats, we have shown that ethanol administration, in the correct dose after stroke onset, protects against ischemia-induced brain injury. The purpose of this paper is to discuss ethanol’s neuroprotective properties in stroke when consumed as a preconditioning agent, in TBI with a positive blood alcohol content, and finally in stroke treatment, with the goal of using post-ischemia ethanol (PIE) therapy to ameliorate brain damage in the future.

Keywords: Ethanol, alcohol, stroke therapy, ischemia/reperfusion injury, traumatic brain injury therapy, neuroprotection


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