Abstract
Background: Although several methods are reported for the synthesis of thiazolidin-4-ones analogues, the microwave assisted method reported in this work is simple and proceeds with high yields in short time.
Methods: In the synthetic method, the targeted thiazolidin-4-ones were synthesized with the help of the microwave by reacting aldehydes, benzyl amine and thioglycolic acid in the presence of zirconium oxychloride and ethanol. Results: All the thiazolidin-4-ones were obtained in good yield (95%-98%) with the help of a microwave technique (6-8 min), in less time as compared to the conventional method (2-4 h). Conclusion: Microwave assisted synthesis will be a useful alternative method for the synthesis of diverse range of thiazolidin-4-ones.Keywords: Aromatic aldehydes, microwave irradiation, ZrOCl2·8H2O.
Graphical Abstract
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