摘要
背景:阿尔茨海默病(AD)以神经元变性、血管病变和认知功能减退为特征。此外,AD患者脑葡萄糖代谢下降和胰岛素抵抗越来越被认可。在调节大脑的形态和功能的预防和早期治疗AD方面,许多改变生活方式的方法,包括饮食和运动,已经取得了可喜的成果。 目的:综述体育锻炼对改善认知,以及限制AD运动病理进展的影响。具体来说,在AD告人和动物模型中,对运动对认知、神经递质、神经、血管的刺激和保护的影响进行了讨论。 结论:研究强调了物理锻炼对改善整体的大脑健康的潜力,这可能会延迟或减少与阿尔茨海默病相关的认知功能障碍和病理。体力活动影响认知功能、血管健康和脑代谢,这些活动为老年人口提供了福利,包括老年痴呆患者。
关键词: 糖尿病,胰岛素,代谢,神经发生,体力活动,可塑性
Current Alzheimer Research
Title:The Benefits of Exercise and Metabolic Interventions for the Prevention and Early Treatment of Alzheimer's Disease
Volume: 14 Issue: 1
Author(s): Ewelina Maliszewska-Cyna, Madelaine Lynch, Jonathan Jordan Oore, Paul Michael Nagy, Isabelle Aubert
Affiliation:
关键词: 糖尿病,胰岛素,代谢,神经发生,体力活动,可塑性
摘要: Background: Alzheimer's disease (AD) is characterized by neuronal degeneration, vascular pathology and cognitive decline. Furthermore, deficits in cerebral glucose metabolism and insulin resistance are being increasingly recognized in AD. Many lifestyle-modifying approaches, including diet and exercise, have yielded promising results in modulating brain morphology and function for the prevention and early treatment of AD.
Objective: This review focuses on the effects of physical exercise on rescuing cognition and limiting the progression of AD pathology. Specifically, the impact of exercise, in human and animal models of AD, on the stimulation and preservation of cognition, neurotransmission, neurogenesis, vasculature, glucose metabolism and insulin signaling is discussed. Conclusion: Studies have highlighted the potential of physical activity to improve overall brain health, which could delay or lessen AD-related cognitive deficits and pathology. Physical activity influences cognitive function, vascular health and brain metabolism, which taken together offers benefits for the aging population, including AD patients.Export Options
About this article
Cite this article as:
Ewelina Maliszewska-Cyna, Madelaine Lynch, Jonathan Jordan Oore, Paul Michael Nagy, Isabelle Aubert , The Benefits of Exercise and Metabolic Interventions for the Prevention and Early Treatment of Alzheimer's Disease, Current Alzheimer Research 2017; 14 (1) . https://dx.doi.org/10.2174/1567205013666160819125400
DOI https://dx.doi.org/10.2174/1567205013666160819125400 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Adverse Drug Reactions Related to Drug Administration in Hospitalized Patients
Current Drug Safety ACAT1 as a Therapeutic Target and its Genetic Relationship with Alzheimer's Disease
Current Alzheimer Research Link Between Chronic Bacterial Inflammation and Alzheimer Disease
CNS & Neurological Disorders - Drug Targets Key Peptides and Proteins in Alzheimer’s Disease
Current Protein & Peptide Science Patent Selections
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery (Discontinued) (Pro)renin Receptor as a New Drug Target
Current Pharmaceutical Design Association and Causal Relationship of Midlife Obesity and Related Metabolic Disorders with Old Age Cognition
Current Alzheimer Research Depot Based Drug Delivery System for the Management of Depression
Current Drug Delivery Aging process, cognitive decline and Alzheimer`s disease: can strength training modulate these responses?
CNS & Neurological Disorders - Drug Targets Patent Selections:
Recent Patents on CNS Drug Discovery (Discontinued) Management Of Elderly Patients With Diffuse Large B-Cell Lymphomas
Anti-Cancer Agents in Medicinal Chemistry Epigenetics in the Cerebrovascular System: Changing the Code without Altering the Sequence
Current Neurovascular Research Donepezil Base: Physicochemical Characterization, HPLC Method Development, Validation and its Application for the Determination of Shelf Life in Developed Solid Lipid Nanoparticles
Current Nanomedicine The Role of β-Amyloid Protein in Synaptic Function: Implications for Alzheimers Disease Therapy
Current Neuropharmacology Implications of Some Selected Flavonoids Towards Alzheimer’s Disease with the Emphasis on Cholinesterase Inhibition and their Bioproduction by Metabolic Engineering
Current Pharmaceutical Biotechnology Thyroid Hormone Levels in the Prefrontal Cortex of Post-Mortem Brains of Alzheimers Disease Patients
Current Aging Science Association Between the Levels of Circulating Adhesion Molecules and Biopterins in Type-2 Diabetic Normotensive Patients Adhesion Molecules and Biopterins
Endocrine, Metabolic & Immune Disorders - Drug Targets Design and Development of Resveratrol NLCs and their Role in Synaptic Transmission of Acetylcholine in C. elegans Model
Current Drug Therapy Neuroprotective Therapies for Alzheimers Disease
Current Pharmaceutical Design Pro-inflammatory Cytokines Modulate Glial Apolipoprotein E Secretion
Current Alzheimer Research