Roles of Insulin Resistance, Endothelial Dysfunction and Lifestyle Changes in the Development of Cardiovascular Disease in Diabetic Patients

Title:Roles of Insulin Resistance, Endothelial Dysfunction and Lifestyle Changes in the Development of Cardiovascular Disease in Diabetic Patients

Volume: 18 Issue: 15

Author(s): Dongdong Sun, Wanrong Man and Lei Zhang*

Affiliation:

• 127 West Changle Road, Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi 710032,China

Keywords: Diabetes mellitus (DM), cardiovascular disease, insulin resistance, endothelium, cardiovascular risk, hyperglycaemia.

Abstract: Background: Diabetes mellitus (DM) caused 1.3 million deaths in 2010, and cardiovascular disease is the leading cause of mortality of diabetic patients. Cardiovascular disease in DM involves complex pathophysiology processes, which are promoted by many risk factors.

Objective: Genetic, epigenetic, lifestyle and environmental factors are responsible for the current epidemic of diabetes and the subsequent increased risk of cardiovascular disease. Over the past years, targets focusing on the increased risk of cardiovascular events in diabetic patients have attracted significant interest.

Conclusion: Within this review, the roles of insulin resistance, endothelial dysfunction and lifestyle changes in the development of cardiovascular disease in diabetic patients are discussed. Potential strategies and challenges in targeting cardiovascular risks in diabetic individuals are also considered.

Cite this article as:

Sun Dongdong, Man Wanrong and Zhang Lei*, Roles of Insulin Resistance, Endothelial Dysfunction and Lifestyle Changes in the Development of Cardiovascular Disease in Diabetic Patients, Current Drug Targets 2017; 18 (15) . https://dx.doi.org/10.2174/1389450117666160715145518