双膦酸盐，骨溶解，骨肉瘤，肺转移，唑来膦酸，骨。

Title:MicroRNAs as Potential Targets for Treatment of Osteoclast-Related Diseases

Volume: 19 Issue: 5

关键词: 药物靶点，miRNAs，破骨细胞，骨溶解疾病，骨稳态，生物发生。

摘要: Background: Understanding the roles of miRNAs in osteoclasts has great potential in the diagnosis and treatment of osteolytic diseases.

Objective: The purpose of this paper was to describe the current knowledge of miRNA biogenesis and summarize recent work on the roles of miRNAs in osteoclasts.

Results: There is accumulating evidence to indicate that miRNAs constitute a novel and efficient mechanism for the regulation of gene expression.

Conclusion: Untangling the role that miRNAs play in osteoclastogenesis will illuminate new strategies and specific drug targets for the treatment of osteolytic diseases. Many questions remain, but an in-depth comprehension of the network and kinetics of miRNAs expression, and their connection with cognate genes will not be trivial, but fruitful.

Cite this article as:

MicroRNAs as Potential Targets for Treatment of Osteoclast-Related Diseases, Current Drug Targets 2018; 19 (5) . https://dx.doi.org/10.2174/1389450117666160502144329