MicroRNAs as Potential Targets for Treatment of Osteoclast-Related Diseases

Title:MicroRNAs as Potential Targets for Treatment of Osteoclast-Related Diseases

Volume: 19 Issue: 5

Author(s): Haowei Li, Zanjing Zhai, Xinhua Qu, Jiake Xu, An Qin*Kerong Dai*

Affiliation:

• Department of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200011,China

• Department of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200011,China

Keywords: Drug targets, miRNAs, osteoclasts, osteolytic diseases, bone homeostasis, biogenesis.

Abstract: Background: Understanding the roles of miRNAs in osteoclasts has great potential in the diagnosis and treatment of osteolytic diseases.

Objective: The purpose of this paper was to describe the current knowledge of miRNA biogenesis and summarize recent work on the roles of miRNAs in osteoclasts.

Results: There is accumulating evidence to indicate that miRNAs constitute a novel and efficient mechanism for the regulation of gene expression.

Conclusion: Untangling the role that miRNAs play in osteoclastogenesis will illuminate new strategies and specific drug targets for the treatment of osteolytic diseases. Many questions remain, but an in-depth comprehension of the network and kinetics of miRNAs expression, and their connection with cognate genes will not be trivial, but fruitful.

Cite this article as:

Li Haowei, Zhai Zanjing, Qu Xinhua, Xu Jiake, Qin An*, Dai Kerong*, MicroRNAs as Potential Targets for Treatment of Osteoclast-Related Diseases, Current Drug Targets 2018; 19 (5) . https://dx.doi.org/10.2174/1389450117666160502144329