Abstract
The G-protein coupled receptor system is involved in a range of cell types and actions and as such has a universal potential in identifying cell functions.
The most widely explored system is that of the somatostatin receptors which has been exploited for both imaging and therapy. However, even with this fairly simple system, variation is seen in the behaviour of cells between patients and within different cell population within the patient.
Newer work will exploit different ligands in a wider range of both tumour types and non-oncological processes such as inflammation.
Keywords: Bombesin, Chemokines, G Protein Coupled Receptors, Inflammation, Imaging, Personalized medicine, Somatostatin Receptors, Targeted Therapy.
Current Pharmaceutical Design
Title:Radiolabeled Probes Targeting G-Protein-Coupled Receptors for Personalized Medicine
Volume: 20 Issue: 14
Author(s): John Buscombe
Affiliation:
Keywords: Bombesin, Chemokines, G Protein Coupled Receptors, Inflammation, Imaging, Personalized medicine, Somatostatin Receptors, Targeted Therapy.
Abstract: The G-protein coupled receptor system is involved in a range of cell types and actions and as such has a universal potential in identifying cell functions.
The most widely explored system is that of the somatostatin receptors which has been exploited for both imaging and therapy. However, even with this fairly simple system, variation is seen in the behaviour of cells between patients and within different cell population within the patient.
Newer work will exploit different ligands in a wider range of both tumour types and non-oncological processes such as inflammation.
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Cite this article as:
Buscombe John, Radiolabeled Probes Targeting G-Protein-Coupled Receptors for Personalized Medicine, Current Pharmaceutical Design 2014; 20 (14) . https://dx.doi.org/10.2174/13816128113196660660
DOI https://dx.doi.org/10.2174/13816128113196660660 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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