摘要
具有SS键的有机化合物,通常称为二硫化物或二硫化物,在各个领域极其重要和有用。它们通常在合成,生物化学,药理学领域表现出独特和多样的化学性质,并广泛用作橡胶和弹性体的硫化剂。在肽和蛋白质化学中,二硫键赋予折叠稳定性,其合成是现代药物化学研究中的关键转变。另一方面,微波(MW)提供热能来源,是常规加热的替代物,并且用于多种化学反应。本文综述了在微波辐射下合成小分子有机二硫化物和带有SS键的无环/环状肽的进展情况,在反应时间和反应效率方面,常常促进了二硫化物的形成。
关键词: 二硫化物,微波,具有S-S键的肽,硫醇,固相肽合成,有机化合物。
Current Medicinal Chemistry
Title:Microwave-assisted Formation of Organic Disulfides of Biochemical Significance
Volume: 24 Issue: 41
关键词: 二硫化物,微波,具有S-S键的肽,硫醇,固相肽合成,有机化合物。
摘要: Organic compounds possessing the –S–S– bond, often called disulfide or disulfane, are extremely important and useful in various fields. They often exhibit unique and diverse chemistry in synthetic, biochemical, pharmacological areas as well as are vastly used as vulcanizing agents for rubbers and elastomers. In peptide and protein chemistry, the disulfide bridges impart stability in folding and their synthesis is a pivotal transformation in modern medicinal chemistry research. On the other hand, microwave (MW) provides heat energy source, an alternative to conventional heating, and is used for diverse chemical reactions. This review has presented the progress towards the synthesis of small organic disulfanes and acyclic/cyclic peptides bearing the –S–S– bond specifically under microwave irradiation, which often facilitated the formation of disulfides over conventional heating both in terms of reaction time and efficiency.
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Cite this article as:
Microwave-assisted Formation of Organic Disulfides of Biochemical Significance, Current Medicinal Chemistry 2017; 24 (41) . https://dx.doi.org/10.2174/0929867323666160418115719
DOI https://dx.doi.org/10.2174/0929867323666160418115719 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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