摘要
脂筏膜微区,特别是富含胆固醇、鞘脂和饱和脂肪酸。这些组织的过多的机制与细胞信号传导、突触中,细胞通讯和细胞存活发挥了关键作用。在过去的几年中,越来越多的证据表明,脂筏可能是与年龄相关的神经病理学改变,如阿尔茨海默病和帕金森病,即使在无症状阶段。特别是,筏脂质组合物中观察到的重要的变化与这些疾病的进展,然后诱导在其物理化学性质的改变。此外,这些现象有助于相关病理事件的丧失,异常蛋白聚集和毒性的细胞信号。在这篇综述中,我们讨论了一些从这些神经退行性疾病的第一阶段发生在脂筏与年龄相关的分子变化相关的数据。随着这些微的改变相关的特定参数的进一步研究可能提供这些神经病理学诊断和预测潜在的工具。
关键词: 阿尔茨海默病,生物标志物,脑脊液,脂筏,脂类,帕金森病,signalosomes。
Current Alzheimer Research
Title:Lipid Raft Alterations in Aged-Associated Neuropathologies
Volume: 13 Issue: 9
Author(s): Raquel Marin, Noemí Fabelo, Cecilia Fernández-Echevarría, Ana Canerina-Amaro, Deiene Rodríguez-Barreto, David Quinto-Alemany and Fátima Mesa-Herrera, Mario Díaz
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关键词: 阿尔茨海默病,生物标志物,脑脊液,脂筏,脂类,帕金森病,signalosomes。
摘要: Lipid rafts are membrane microdomains particularly enriched in cholesterol, sphingolipids and saturated fatty acids. These microstructures play a key role in a plethora of mechanisms involved in cell signaling, synapsis, cell-cell communication and cell survival. In the last years, increasing evidence indicate that lipid rafts may be altered in age-related neuropathologies, such as Alzheimer’s disease and Parkinson disease even at asymptomatic stages. In particular, important changes in raft lipid composition are observed with the progression of these diseases, then inducing alterations in their physicochemical properties. Furthermore, these phenomena contribute to neuropathological events related to amyloidogenesis, aberrant protein aggregation and toxic cell signalling. In this review, we discuss some relevant data on the age-related molecular changes occurring in lipid rafts since the first stages of these neurodegenerative diseases. Further characterization of specific parameters associated with alterations of these microdomains may provide potential tools of diagnosis and prediction of these neuropathologies.
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Raquel Marin, Noemí Fabelo, Cecilia Fernández-Echevarría, Ana Canerina-Amaro, Deiene Rodríguez-Barreto, David Quinto-Alemany and Fátima Mesa-Herrera, Mario Díaz , Lipid Raft Alterations in Aged-Associated Neuropathologies, Current Alzheimer Research 2016; 13 (9) . https://dx.doi.org/10.2174/1567205013666160314150017
DOI https://dx.doi.org/10.2174/1567205013666160314150017 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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