内质网应激和自噬

Title:ER Stress and Autophagy

Volume: 15 Issue: 8

Author(s): W. -S. Lee, W. -H. Yoo and H. -J. Chae

Affiliation:

关键词: 自噬，分子伴侣，内质网应激，细胞凋亡，未折叠蛋白反应。

摘要: Eukaryotic cells respond to various types of stresses caused by changes in the extracellular environment. Intracellular factors, such as the accumulation of misfolded proteins in the endoplasmic reticulum (ER), also cause stress and activate the unfolded protein response (UPR), which induces the expression of chaperones and proteins involved in the recovery process. However, if the stress is excessive or sustained, and ER function cannot be restored, the UPR triggers apoptosis, thereby removing the affected cell. It is now apparent that ER stress is also a potent trigger for autophagy, a self-degradative process that has an adaptive function. This review surveys the intersection of ER stress and autophagy and highlights the potential therapeutic implications thereof.

Cite this article as:

W. -S. Lee, W. -H. Yoo and H. -J. Chae , ER Stress and Autophagy, Current Molecular Medicine 2015; 15 (8) . https://dx.doi.org/10.2174/1566524015666150921105453