Targeted Therapy for Glioblastoma: Lessons Learned and Future Directions

Title:Targeted Therapy for Glioblastoma: Lessons Learned and Future Directions

Volume: 11 Issue: 1

Author(s): Nicole A Shonka, Suprit Gupta and Pankaj K. Singh

Affiliation:

Keywords: Cell signaling, glioblastoma, gliomagenesis, monoclonal antibodies, targeted therapy, tyrosine kinase inhibitors.

Abstract: Glioblastoma is the most common adult malignant primary brain tumor, and carries a dismal prognosis. After initial standard radiation therapy and chemotherapy with temozolomide, few standard chemotherapy options are available. In the last two decades, a growing understanding of molecular pathogenesis of glioblastoma has turned our focus toward targeted therapy. This review will discuss our current understanding of gliomagenesis and highlight the clinical attempts to manipulate these vital pathways, describing past and current studies, and future directions.

Cite this article as:

Shonka A Nicole, Gupta Suprit and Singh K. Pankaj, Targeted Therapy for Glioblastoma: Lessons Learned and Future Directions, Current Cancer Therapy Reviews 2015; 11 (1) . https://dx.doi.org/10.2174/157339471101150706122425