幽门螺杆菌的药物靶点识别的生物信息学分析：可能的治疗胃癌的意义

Title:Identification of Drug Targets in Helicobacter pylori by in silico Analysis : Possible Therapeutic Implications for Gastric cancer

Volume: 16 Issue: 1

Author(s): Deepthi Nammi, Ravi C. P. K. Srimath-Tirumala-Peddinti and Nageswara Rao R. Neelapu

Affiliation:

关键词: 药物靶点，基因组分析，宿主与病原体的比较，蛋白质组的比较，菌株-菌株的比较，物种-物种的比较

摘要: Helicobacter pylori colonize stomach, inducing gastritis, ulcers and gastric cancer. Drugs are used to relieve pain, but not H. pylori infections. Hence, there is a need for discovery of drug targets and drugs for H. pylori. An objective of this current study is to identify drug targets for H. pylori. RAST was used to compare genomes of 23 H. pylori strains with Homo sapiens sapiens, other Helicobacter species (H. acinonychis, H. hepaticus, H. mustalae) and among them, to identify 13471 unique genes. Bacterial genes which are non-homologous to humans and essential for pathogen are identified using BLASTp. Later, 29 potential drug targets were identified by subjecting these genes to property analysis. Eleven of the 29 drug targets are already experimentally validated, lending credence to our approach. These methods have enabled rapid identification of drug targets with possible therapeutic implications for gastric cancer.

Cite this article as:

Deepthi Nammi, Ravi C. P. K. Srimath-Tirumala-Peddinti and Nageswara Rao R. Neelapu , Identification of Drug Targets in Helicobacter pylori by in silico Analysis : Possible Therapeutic Implications for Gastric cancer, Current Cancer Drug Targets 2016; 16 (1) . https://dx.doi.org/10.2174/1568009615666150602143239