Revision of the Synthesis and Pharmacological Activity of a Reported Translation Inhibitor

Title:Revision of the Synthesis and Pharmacological Activity of a Reported Translation Inhibitor

Volume: 15 Issue: 10

Author(s): Christine Basmadjian, Helene Malka-Mahieu and Laurent Desaubry

Affiliation:

Keywords: Cancer, eIF4E, metastatic melanoma, mRNA translation, protein synthesis, thiazoles.

Abstract: 4EGI-1 is the prototype of a novel class of anticancer agents targeting translation. Patented drug-like analogue 1 was synthesized and examined for inhibition of translation and cytotoxicity in cancer cells. Unexpectedly, 1 was found inactive in both assays.

Cite this article as:

Basmadjian Christine, Malka-Mahieu Helene and Desaubry Laurent, Revision of the Synthesis and Pharmacological Activity of a Reported Translation Inhibitor, Anti-Cancer Agents in Medicinal Chemistry 2015; 15 (10) . https://dx.doi.org/10.2174/1871520615666150602092450