PPARδ Signaling Regulates Colorectal Cancer

Title:PPARδ Signaling Regulates Colorectal Cancer

Volume: 21 Issue: 21

Author(s): Mengli You, Shuping Yuan, Juanjuan Shi and Yongzhong Hou

Affiliation:

Keywords: Colorectal cancer, PPARδ, signaling.

Abstract: Peroxisome proliferator-activated receptorδ (PPARδ) belongs to the PPARs receptor family including PPARα, PPARδ, and PPARγ. PPARδ is a ligand-activated transcription factor that plays a critical role in regulating cancer progression. PPARδ-linked tumorigenesis was first identified in colorectal cancer, which is demonstrated by the following evidences, so PPARε is a potential drug target for colorectal cancer. In contrast, some observations show that PPARδ negatively regulates colorectal cancer event. In the present review, the recent progress of PPARδ signaling-mediated colorectal cancer is covered.

Cite this article as:

You Mengli, Yuan Shuping, Shi Juanjuan and Hou Yongzhong, PPARδ Signaling Regulates Colorectal Cancer, Current Pharmaceutical Design 2015; 21 (21) . https://dx.doi.org/10.2174/1381612821666150514104035