血栓形成的病理和血栓闭塞性脉管炎有效治疗管理的挑战性

Title:Mechanisms of Thrombosis, Available Treatments and Management Challenges Presented by Thromboangiitis Obliterans

Volume: 22 Issue: 16

Author(s): Bahare Fazeli and Hassan Ravari

Affiliation:

关键词: 血栓闭塞性脉管炎， 一氧化氮，血栓闭塞性脉管炎，溶栓，血栓症，治疗

摘要: Thromboangiitis obliterans (TAO) is a thrombotic-occlusive and an inflammatory peripheral arterial disease with unidentified aetiology. Thrombotic events can lead to limb loss in TAO patients, who are typically young male smokers of low socioeconomic status. It is still unknown whether the initial process is thrombosis or inflammation, so it is difficult to ascertain whether managing inflammation or thrombosis improves the outcome of the disease. In this review, the possible mechanisms of thrombosis in TAO are evaluated; the treatments, based on the discussed mechanisms of thrombosis in TAO, are then reviewed and the challenges and limitations associated with the management of TAO are discussed.

Cite this article as:

Bahare Fazeli and Hassan Ravari , Mechanisms of Thrombosis, Available Treatments and Management Challenges Presented by Thromboangiitis Obliterans, Current Medicinal Chemistry 2015; 22 (16) . https://dx.doi.org/10.2174/0929867322666150429112111