Insights into Immunophilin Structure and Function

Title: Insights into Immunophilin Structure and Function

Volume: 18 Issue: 35

Author(s): C. Lucke and M. Weiwad

Affiliation:

Keywords: Calcineurin, cyclophilin, FK506-binding protein, immunophilin, immunosuppression, PPIase domain, peptidyl-prolyl bonds, topology, hydrophobic cyclic, hydrophobic macrolides

Abstract: The immunophilins are proteins which are capable of influencing the immune response in combination with an immunosuppressive drug. Their natural function, however, is mainly the cis/trans isomerization of peptidyl-prolyl bonds in other proteins. This review lists all immunophilin structure coordinates currently available in the RCSB protein data bank and highlights the key active-site factors that define their catalytic and immunological action. In addition, an overview of biologically-relevant functions is provided for various immunophilin members.

Cite this article as:

Lucke C. and Weiwad M., Insights into Immunophilin Structure and Function, Current Medicinal Chemistry 2011; 18 (35) . https://dx.doi.org/10.2174/092986711798194324