Immunossupressant and Organ Transplantation: Immunophilins Targeting Agent and Alternative Therapies

J.      J. Cubero; E.      Lopez; P.      C. Redondo; R.      Alvarado; G.      Pino; A.      Cubero; A.      Martinez; F.      Ferreira; J.      Villa; C.      Martinez

doi:10.2174/092986711798194423

Abstract

Since the first attempt to replace a dysfunctional organ, clinics and scientific had to overcome many setbacks in order to warrant the success and viability of both the organ and the receptor. Despite the improvement of surgical procedures, some grafts fail within the following days or week due to immunologic rejection. Many ongoing researches are still seeking the perfect immunossupresors. Calcineurin targeting agents have been consolidated as a worldwide immnunossupressant therapy, but due to its widely functional role in many cell types, this strategy often represents a highly risk therapy due to side effects observed with these agents. Here we summarized the latest and past knowledge regarding immunossupression therapies, including the promising and widely used Immunophilin-targeting antagonist therapies.

Keywords: Transplantation, immunossupressant, FK506, CsA, Rapamycin, kidney transplantation, Calcineurin targeting, Immunophilin-targeting, antagonist therapies, Mythology