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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Ligands of Diltiazem Binding Site: An Overview of Some Chemotypes

Author(s): R. Budriesi, P. Ioan, E. Carosati, G. Cruciani, B. S. Zhorov and A. Chiarini

Volume 9, Issue 12, 2009

Page: [1379 - 1388] Pages: 10

DOI: 10.2174/138955709789957369

Price: $65

Abstract

The diltiazem binding site of L-type calcium channels is the least characterized to date. In this paper, we present some of the available chemotypes that bind to the benzothiazepine binding site: natural compounds, compounds synthesized by varying the benzothiazepine scaffold, and compounds discovered by means of computational approaches.

Keywords: (+)-cis-Diltiazem, L-type calcium channels, benzothiazepine, chemotype, computational approaches, voltage gated calcium channel, calcium entry blockers, structural and functional analogs


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