Abstract
8-Azapurine nucleus is a bioisoster of the purine nucleus. Variously substituted 8-azapurines have been synthesised and studied for their interactions with many enzymes and receptors and for their antitumor and antiviral activity. In this paper the main results of the studies made in these last years on this topic are reported.
Keywords: 8-Azapurines, 1,2,3-triazolo[4,5-d]pyrimidines, adenosine deaminase inhibitors, xanthine oxidase inhibitors, adenosine receptor ligands, antitumor and antiviral agents
Mini-Reviews in Medicinal Chemistry
Title: 8-Azapurine Nucleus: A Versatile Scaffold for Different Targets
Volume: 9 Issue: 12
Author(s): I. Giorgi and V. Scartoni
Affiliation:
Keywords: 8-Azapurines, 1,2,3-triazolo[4,5-d]pyrimidines, adenosine deaminase inhibitors, xanthine oxidase inhibitors, adenosine receptor ligands, antitumor and antiviral agents
Abstract: 8-Azapurine nucleus is a bioisoster of the purine nucleus. Variously substituted 8-azapurines have been synthesised and studied for their interactions with many enzymes and receptors and for their antitumor and antiviral activity. In this paper the main results of the studies made in these last years on this topic are reported.
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Cite this article as:
Giorgi I. and Scartoni V., 8-Azapurine Nucleus: A Versatile Scaffold for Different Targets, Mini-Reviews in Medicinal Chemistry 2009; 9 (12) . https://dx.doi.org/10.2174/138955709789957440
DOI https://dx.doi.org/10.2174/138955709789957440 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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