Generic placeholder image

Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Genesis of Dihydropyrimidinone Calcium Channel Blockers: Recent Progress in Structure-Activity Relationships and Other Effects

Author(s): K. Singh, D. Arora and S. Singh

Volume 9, Issue 1, 2009

Page: [95 - 106] Pages: 12

DOI: 10.2174/138955709787001686

Price: $65

Abstract

In the armamentarium of calcium channel blockers appropriately functionalized 3,4-dihydropyrimidin-2(1H)- ones have received considerable attention in recent past owing to their structural similarity with 1,4-dihydropyridine based drugs. In this review, we highlight detailed investigations in the calcium channel blocking and other activities of this category of compounds as well as trace their genesis from 1,4-dihydropyridine based drugs.

Keywords: Dihydropyridines, dihydropyrimidines, dihydropyrimidinones, calcium channel blockers, mitotic kinesin inhibitors, α-adrenergic receptor antagonists, structure- activity relationships


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy