Post-Translational Modification of Transcription Factors: Mechanisms and Potential Therapeutic Interventions

Title:Post-Translational Modification of Transcription Factors: Mechanisms and Potential Therapeutic Interventions

Volume: 6

Author(s): Sonia L. Planey, Raj Kumar and John A. Arnott

Affiliation:

Keywords: Drug development, gene regulation, post-translational modifications, transcription factors, .

Abstract: Transcription factors (TFs) orchestrate multiple cellular processes through tight regulation via post-translational modifications (PTMs). Thus, decoding the combinations of PTMs should provide critical layer of information that can be integrated into highly specific cellular outputs to reveal a network of genes and their target-specific regulation. Protein modifications play a decisive role in various drug responses and eventually in prognosis for many life-threatening diseases, and recent studies demonstrate that TF-based drug designing must consider structural and functional changes due to PTMs, yet we are just beginning to grasp this enormity and the impact on normal development and disease pathophysiology.

Cite this article as:

Planey L. Sonia, Kumar Raj and Arnott A. John, Post-Translational Modification of Transcription Factors: Mechanisms and Potential Therapeutic Interventions, Current Molecular Pharmacology 2013; 6 (3) . https://dx.doi.org/10.2174/1874467207666140307124241