STAT3 as a Therapeutic Target for Glioblastoma

Title: STAT3 as a Therapeutic Target for Glioblastoma

Volume: 10 Issue: 7

Author(s): Yan Liu, Chenglong Li and Jiayuh Lin

Affiliation:

Keywords: Cytokine, glioblastoma, glioblastoma stem cells, growth factor, STAT3, STAT3 inhibitor.

Abstract: Glioblastoma (GBM) is the most common type of primary malignant brain tumor. Despite advances in surgical resection, radiotherapy and chemotherapy, prognosis remains very poor. Accordingly, recent studies have been focused on the aberrant signal transduction pathways in glioblastoma. Many patient derived primary glioblastomas and cell lines express constitutively activated signal transducers and activators of transcription 3 (STAT3). Here we focused on the recent progresses regarding to the roles of STAT3 in glioblastoma and glioblastoma stem cells (GBM-SCs), the dysregulation of STAT3 in glioblastoma, and targeting STAT3 for glioblastoma therapy.

Cite this article as:

Liu Yan, Li Chenglong and Lin Jiayuh, STAT3 as a Therapeutic Target for Glioblastoma, Anti-Cancer Agents in Medicinal Chemistry 2010; 10 (7) . https://dx.doi.org/10.2174/187152010793498636