Abstract
The blood brain barrier, formed by brain capillary endothelial cells, represents the major obstacle for drug entry into the central nervous system. Efforts are ongoing to overcome this barrier without causing permanent damage to brain tissue. The present review attempts to provide key information on cerebral microvessel anatomy, features contributing to barrier function and current approaches in overcoming the blood-brain barrier using cellular and molecular methodologies to transfer drugs to the brain as well as intelligent drug delivery systems.
Keywords: blood-brain barrier, p-glycoprotein, drug delivery systems, nanoparticles, Immuno-liposomes
Related Books
Nanotechnology: A Quick Guide to Materials and Technologies
Recent Advancements in Multidimensional Applications of Nanotechnology
Thin Film Nanomaterials: Synthesis, Properties and Innovative Energy Applications
Advanced Materials and Nano Systems: Theory and Experiment (Part 3)
Nanoelectronic Devices and Applications
Nanoscale Field Effect Transistors: Emerging Applications
Nanoelectronics Devices: Design, Materials, and Applications Part II
Nanoelectronics Devices: Design, Materials, and Applications (Part I)
Role of Nanotechnology in Cancer Therapy
Synthesis and Applications of Semiconductor Nanostructures
1