Abstract
Cancer is a leading cause of mortality worldwide, being responsible for millions of deaths annually. Therefore, novel cancer chemotherapeutic agents are urgently needed to combat this devastating disease. β - Carboline alkaloids are an important class of natural products and medicinal molecules, which exert their anticancer activities through diverse mechanisms. In this review, we cover recent natural and synthetic β - carbolines with anticancer activity that have been reported in the literature (2010-July 2014), focusing on their chemical structures, anticancer properties, structure-activity relationships, and mechanisms of action.
Keywords: Alkaloid, Anticancer, Antitumor, β -Carboline, Mechanism of action, Natural product, Structureactivity relationship.
Graphical Abstract
Anti-Cancer Agents in Medicinal Chemistry
Title:Recent Advances of Natural and Synthetic β-Carbolines as Anticancer Agents
Volume: 15 Issue: 5
Author(s): Mingming Zhang and Dianqing Sun
Affiliation:
Keywords: Alkaloid, Anticancer, Antitumor, β -Carboline, Mechanism of action, Natural product, Structureactivity relationship.
Abstract: Cancer is a leading cause of mortality worldwide, being responsible for millions of deaths annually. Therefore, novel cancer chemotherapeutic agents are urgently needed to combat this devastating disease. β - Carboline alkaloids are an important class of natural products and medicinal molecules, which exert their anticancer activities through diverse mechanisms. In this review, we cover recent natural and synthetic β - carbolines with anticancer activity that have been reported in the literature (2010-July 2014), focusing on their chemical structures, anticancer properties, structure-activity relationships, and mechanisms of action.
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Cite this article as:
Zhang Mingming and Sun Dianqing, Recent Advances of Natural and Synthetic β-Carbolines as Anticancer Agents, Anti-Cancer Agents in Medicinal Chemistry 2015; 15 (5) . https://dx.doi.org/10.2174/1871520614666141128121812
DOI https://dx.doi.org/10.2174/1871520614666141128121812 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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