Fluorescent Molecular Imaging: Technical Progress and Current Preclinical and Clinical Applications in Urogynecologic Diseases

Title:Fluorescent Molecular Imaging: Technical Progress and Current Preclinical and Clinical Applications in Urogynecologic Diseases

Volume: 13 Issue: 10

Author(s): V. M. Alexander, P. L. Choyke and H. Kobayashi

Affiliation:

Keywords: Gynecologic cancer, molecular imaging, near infrared, urologic cancer.

Abstract: Many molecular imaging probes have been developed in recent years that hold great promise for both diagnostic and therapeutic functions in urogynecologic disease. Historically, optical probe designs were based on either endogenous or exogenous fluorophores. More recently, organic fluorophore probes have been engineered to target specific tissues and emit fluorescence only upon binding to targets. Several different photochemical mechanisms of activation exist. This review presents a discussion of the history and development of molecular imaging probe designs and provides an overview of successful preclinical and clinical models employing molecular probes for in vivo imaging of urogynecologic cancers.

Cite this article as:

Alexander M. V., Choyke L. P. and Kobayashi H., Fluorescent Molecular Imaging: Technical Progress and Current Preclinical and Clinical Applications in Urogynecologic Diseases, Current Molecular Medicine 2013; 13 (10) . https://dx.doi.org/10.2174/1566524013666131111125758