Synthesis of 2-Amino-4H-Chromen-4-yl Phosphonats via C-P Bond Formation Catalyzed by Nano-Rods ZnO Under Solvent-Free Condition

Title:Synthesis of 2-Amino-4H-Chromen-4-yl Phosphonats via C-P Bond Formation Catalyzed by Nano-Rods ZnO Under Solvent-Free Condition

Volume: 17 Issue: 1

Author(s): Mona Hosseini-Sarvari and Atefeh Roosta

Affiliation:

Keywords: 2-amino-4H-chromen-4-yl phosphonate, nano rods ZnO, solvent-free, three-component reactions.

Abstract: One-pot, three-component reactions of structurally diverse salicylaldehydes with malononitrile (or ethylcyanoacetate) and diethyl (or dimethyl) phosphate are carried out in the presence of nano-rods ZnO as an efficient catalyst for the synthesis of biologically interesting 2-amino-4H-chromen-4-yl phosphonate derivatives. The value of this method lies in its mild and environmentally benign reaction, simple procedure, good yields, and ease of handling.

Cite this article as:

Hosseini-Sarvari Mona and Roosta Atefeh, Synthesis of 2-Amino-4H-Chromen-4-yl Phosphonats via C-P Bond Formation Catalyzed by Nano-Rods ZnO Under Solvent-Free Condition, Combinatorial Chemistry & High Throughput Screening 2014; 17 (1) . https://dx.doi.org/10.2174/13862073113166660064