Immune Response, Diagnosis and Treatment of Allergic Bronchopulmonary Aspergillosis in Cystic Fibrosis Lung Disease

Title:Immune Response, Diagnosis and Treatment of Allergic Bronchopulmonary Aspergillosis in Cystic Fibrosis Lung Disease

Volume: 19 Issue: 20

Author(s): Olaf Eickmeier, Nikolaus Rieber, Jonas Eckrich, Andreas Hector, Ute Graeppler-Mainka and Dominik Hartl

Affiliation:

Keywords: Cystic fibrosis, Allergic Bronchopulmonary Aspergillosis (ABPA), Immune response.

Abstract: Patients with cystic fibrosis (CF) suffer from chronic infective lung disease, which determines morbidity and mortality. While bacteria, such as Pseudomonas aeruginosa, are well-known to contribute to pulmonary pathology, the relevance of fungi in CF airways remains poorly understood. The best studied fungus in CF is Aspergillus fumigatus, which frequently colonizes CF airways and causes a disease condition termed allergic bronchopulmonary aspergillosis. This review aims to provide an update on the immunological mechanisms, diagnostic approaches and therapeutic strategies for allergic bronchopulmonary aspergillosis and other Aspergillus fumigatusmediated phenotypes in CF lung disease.

Cite this article as:

Eickmeier Olaf, Rieber Nikolaus, Eckrich Jonas, Hector Andreas, Graeppler-Mainka Ute and Hartl Dominik, Immune Response, Diagnosis and Treatment of Allergic Bronchopulmonary Aspergillosis in Cystic Fibrosis Lung Disease, Current Pharmaceutical Design 2013; 19 (20) . https://dx.doi.org/10.2174/13816128113199990349