Ionic Liquid Mediated Synthesis of Novel tetrahydroimidazo [1,2- a]pyrimidine-6-carboxylate Derivatives

Title:Ionic Liquid Mediated Synthesis of Novel tetrahydroimidazo [1,2- a]pyrimidine-6-carboxylate Derivatives

Volume: 10 Issue: 3

Author(s): Vinod V. Thorat, Satish A. Dake, Satish U. Deshmukh, Elayaraja Rasokkiyam, Mohd. Farees Uddin and Rajendra P. Pawar

Affiliation:

Keywords: Aromatic aldehydes, Biginelli reaction, Catalyst, Ionic liquid, 5-amino-4, 5-dihydro-1H-pyrazole-4-carbonitrile

Abstract: A novel route for the synthesis of tetrahydroimidazo [1,2-a] pyrimidine-6-carboxylate derivatives in presence of 1-ethyl-3-methyl imidazolium hydrogen sulphate ionic liquid at room temperature has been reported via Biginelli reaction. The process offer several advantages such as short reaction time, excellent yield of products, simple work up procedure etc. 1-ethyl-3-methyl imidazolium hydrogen sulphate ionic liquid is utilized as solvent system and catalyst to enhance the rate of reactions.

Cite this article as:

V. Thorat Vinod, A. Dake Satish, U. Deshmukh Satish, Rasokkiyam Elayaraja, Farees Uddin Mohd. and P. Pawar Rajendra, Ionic Liquid Mediated Synthesis of Novel tetrahydroimidazo [1,2- a]pyrimidine-6-carboxylate Derivatives, Letters in Organic Chemistry 2013; 10 (3) . https://dx.doi.org/10.2174/1570178611310030006