Progress in Synthesis and Antitumor Activities of Estradiol-linked Platinum Complex

Title:Progress in Synthesis and Antitumor Activities of Estradiol-linked Platinum Complex

Volume: 13 Issue: 2

Author(s): Ping Zhang, Ye-wei Yang and Zheng-rong Shen

Affiliation:

Keywords: Estradiol-linked platinum complex, Cisplatin, Target therapy, Antitumor activity, Cytotoxicity, Breast cancer

Abstract: Platinum complexes such as cisplatin and caboplatin are widely used in cancer chemotherapy. However, their clinical applications are substantially limited by unexpected toxic side effects. In this review, we discuss the current progress on the design and synthesis of estradiol-linked platinum complexes as the targeted antitumor drugs. Many of them display a high antitumor activity against the growth of breast cancer cell lines in vitro. The estradiol-linked platinum complexes could be used as target therapeutics for breast cancer.

Cite this article as:

Zhang Ping, Yang Ye-wei and Shen Zheng-rong, Progress in Synthesis and Antitumor Activities of Estradiol-linked Platinum Complex, Mini-Reviews in Medicinal Chemistry 2013; 13 (2) . https://dx.doi.org/10.2174/1389557511313020008