Hybrid Bioactive Hydrogels Containing Single-Walled Carbon Nanotubes Covalently Integrated via Strain-Promoted Azide-Alkyne Cycloaddition

Title:Hybrid Bioactive Hydrogels Containing Single-Walled Carbon Nanotubes Covalently Integrated via Strain-Promoted Azide-Alkyne Cycloaddition

Volume: 2 Issue: 2

Author(s): Jurgen Bachl, Thimo Huber, Dennis Kuhbeck, Eva-Maria Schon, Gabriele Brunner, Birgit Kraus, Jorg Heilmann, Julian A. Codelli, Carolyn R. Bertozzi, Carlos Cativiela and David Diaz Diaz

Affiliation:

Keywords: Single-walled carbon nanotubes, ‘click’ chemistry, strain-promoted reactions, hydrogels, cytotoxicity

Abstract: A non-photochemical and metal-free orthogonal route for the covalent incorporation of single-walled carbon nanotubes into a κ-carrageenan-based bioactive hydrogel scaffold is reported. The characterization of materials was carried out by usual analytical techniques and hybrid biohydrogels were evaluated for in vitro cytotoxicity on HeLa cell lines. The results revealed a significant antiproliferative effect instead of additional cytotoxicity with respect to native hydrogels.

Cite this article as:

Bachl Jurgen, Huber Thimo, Kuhbeck Dennis, Schon Eva-Maria, Brunner Gabriele, Kraus Birgit, Heilmann Jorg, A. Codelli Julian, R. Bertozzi Carolyn, Cativiela Carlos and Diaz Diaz David, Hybrid Bioactive Hydrogels Containing Single-Walled Carbon Nanotubes Covalently Integrated via Strain-Promoted Azide-Alkyne Cycloaddition, Nanoscience & Nanotechnology-Asia 2012; 2 (2) . https://dx.doi.org/10.2174/2210681211202020200