Anti-Inflammatory Trends of 1, 3-Diphenyl-2-propen-1-one Derivatives

Title:Anti-Inflammatory Trends of 1, 3-Diphenyl-2-propen-1-one Derivatives

Volume: 13 Issue: 1

Author(s): Syed Nasir Abbas Bukhari, Ibrahim Jantan and Malina Jasamai

Affiliation:

Keywords: Chalcones, Anti-inflammatory, Lipid peroxidation, Heme oxygenase1(HO-1), Cyclooxygenase (COX), Interleukin 5 (IL-5), Nitric oxide (NO)

Abstract: Chalcones (1, 3-Diphenyl-2-propen-1-one) are constituted by a three carbon α, β-unsaturated carbonyl system. The biosynthesis of flavonoids and isoflavonoids is initiated by chalcones. Notable pharmacological activities of chalcones and its derivatives include anti-inflammatory, antifungal, antibacterial, antimalarial, antituberculosis, antitumor, antimicrobial and antiviral effects respectively. Owing to simplicity of the chemical structures and a huge variety of pharmacological actions exhibited, the entities derived from chalcones are subjected to extensive consideration. This review article is an effort to sum up the anti-inflammatory activities of chalcone derived chemical entities. Effect of chalcones on lipid peroxidation, heme oxygenase 1(HO-1), cyclooxygenase (COX), interleukin 5 (IL-5), nitric oxide (NO) and expression of cell adhesion molecules (CAM) is summarized stepwise.

Cite this article as:

Nasir Abbas Bukhari Syed, Jantan Ibrahim and Jasamai Malina, Anti-Inflammatory Trends of 1, 3-Diphenyl-2-propen-1-one Derivatives, Mini-Reviews in Medicinal Chemistry 2013; 13 (1) . https://dx.doi.org/10.2174/1389557511307010087