Evaluation of Angiogenesis with the Expression of VEGF-C and CD34 in Human Colon Cancer

Ana   Maria   Inda; Marcela   Nilda   Garcia; Laura   Beatriz   Andrini; Adriana   Laura   Garcia; Ayelen   Fernandez   Blanco; Cecilia   Cristina   Furnus; Susana   Mercedes   Galletti; Javier      Brandoni; Jorge   Guillermo   Martinez; Guillermo   Daniel   Prat; Ana   Lia   Errecalde

doi:10.2174/2212796810903030302

Abstract

Background: The most potent angiogenic factor is the vascular endothelial growth factor (VEGF), and CD34 is an endothelial antigen that has been used to highlight the microvasculature vessel density (MVD) as a direct marker of the degree of neoangiogenesis. In the present study we report that VEGF expression and its relationship with MVD, in poorly and well differentiated colon adenocarcinoma, in order to consider the possibility of using the correlation between both antibodies as a prognostic factor. Materials and Methods: Tumor sections were stained by immunohistochemistry for CD34 and VEGF. Results: The mean of VEGF and CD34 did not show any significant differences between both types of tumors. Conclusion: The conventional factors taken into consideration were not significantly related to the angiogenic factors examined, so we could affirm that the correlation of both markers could be useful as prognostic factor.

Keywords: Colon cancer, VEGF, CD34, angiogenesis, colon, adenocarcinoma

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