Roles of Laminin-332 and α6β4 Integrin in Tumor Progression

Title: Roles of Laminin-332 and α6β4 Integrin in Tumor Progression

Volume: 9 Issue: 11

Author(s): Y. Kariya, Y Kariya and J. Gu

Affiliation:

Keywords: Laminin-332, α6β4 integrin, basement membrane, extracellular matrix, tumor, cell migration, cell adhesion, ErbB2

Abstract: Laminin-332 and α6β4 integrin is major hemidesmosome components in the skin. As many studies have shown that laminin-332 and α6β4 integrin play important roles in tumor progression via activation of phosphatidylinositol-3 kinase signaling, understanding of the molecular mechanisms of them could lead to a new drug for cancer therapy.

Cite this article as:

Kariya Y., Y Kariya and Gu J., Roles of Laminin-332 and α6β4 Integrin in Tumor Progression, Mini-Reviews in Medicinal Chemistry 2009; 9 (11) . https://dx.doi.org/10.2174/138955709789878114