Inhibitors of HMG-CoA Reductase: Current and Future Prospects

Title: Inhibitors of HMG-CoA Reductase: Current and Future Prospects

Volume: 9 Issue: 11

Author(s): Narender Singh, Joaquin Tamariz, German Chamorro and Jose L. Medina-Franco

Affiliation:

Keywords: 3-hydroxy-3-methylglutaryl-coenzyme A reductase, α-asarone, cardiovascular disease, low density lipoproteins, cholesterol, statins, side effects, structure-based drug design

Abstract: High levels of cholesterol are a primary risk factor in the development of cardiovascular diseases. In this review, we have summarized the structural, chemical and computational aspects of hypocholesterolemic drugs, both statins and non-statins, that target enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA) to block cholesterol biosynthesis.

Cite this article as:

Singh Narender, Tamariz Joaquin, Chamorro German and Medina-Franco L. Jose, Inhibitors of HMG-CoA Reductase: Current and Future Prospects, Mini-Reviews in Medicinal Chemistry 2009; 9 (11) . https://dx.doi.org/10.2174/138955709789878105