The Intriguing Phospholipases A2 Homologues: Relevant Structural Features on Myotoxicity and Catalytic Inactivity

Title: The Intriguing Phospholipases A2 Homologues: Relevant Structural Features on Myotoxicity and Catalytic Inactivity

Volume: 16 Issue: 8

Author(s): Juliana I. dos Santos, Carlos A.H. Fernandes, Angelo J. Magro and Marcos R.M. Fontes

Affiliation:

Keywords: Phospholipase A2 homologues, snake venom, oligomeric conformation, quaternary structure, myotoxicity, X-ray crystallography

Abstract: Phospholipases A2 homologues are found in the venom of Crotalinae snakes, being their main action related to myonecrosis induction. Although many studies on these toxins had already been performed, their mechanism of action remains unclear. Here, important aspects about these toxins are reviewed, including their correct biological assembly and how essential is the natural substitution D49K for their catalytic inactivity.

Cite this article as:

dos Santos I. Juliana, Fernandes A.H. Carlos, Magro J. Angelo and Fontes R.M. Marcos, The Intriguing Phospholipases A2 Homologues: Relevant Structural Features on Myotoxicity and Catalytic Inactivity, Protein & Peptide Letters 2009; 16 (8) . https://dx.doi.org/10.2174/092986609788923310