PSMA7, A Potential Biomarker of Diseases

Title: PSMA7, A Potential Biomarker of Diseases

Volume: 16 Issue: 5

Author(s): Hongyan Du, Xiang Huang, Suihai Wang, Yingsong Wu, Weiwen Xu and Ming Li

Affiliation:

Keywords: PSMA7, ubiquitin-proteasome pathway, proteasome, disease tumor

Abstract: Proteasome subunit alpha type 7(PSMA7) is an α-type subunit of the 20S proteasome core complex and participates in degrading proteins through ubiquitin-proteasome pathway (UPP) which plays an important role in the regulation of cell proliferation or cell cycle control, transcriptional regulation, immune and stress response, cell differentiation, and apoptosis. Previous studies have demonstrated that PSMA7 can be a target interacting with some important proteins involved in transcription factor regulation, cell cycle transition, viral replication and even tumor initiation and progression, suggesting that PSMA7 could be a potential target for the development of clinical diagnosis and new therapeutic drugs. Here, we review the recent studies on PSMA7 involved in many different cellular processes, ranging from the cell cycle process to antigen processing and tumorigenesis.

Cite this article as:

Du Hongyan, Huang Xiang, Wang Suihai, Wu Yingsong, Xu Weiwen and Li Ming, PSMA7, A Potential Biomarker of Diseases, Protein & Peptide Letters 2009; 16 (5) . https://dx.doi.org/10.2174/092986609788167824