Interaction Profiling of T-Cell Epitopes with MHC-Class I Molecules

Banaja Priyardarshini Dash; Sumanto Mukherjee; V.L. Suhas; Nagasuma Chandra

doi:10.2174/092986607780989994

Abstract

A key step in rational vaccine development is to understand how antigens are recognized by their receptors. Several crystal structures of MHC/HLA molecules are now available. We report a structural bioinformatics study of peptide- HLA complexes to derive features that generate recognition specificity, useful for guiding the design process.

Keywords: Epitope prediction, protein-peptide interaction, HLA class-I, vaccine design, structural bioinformatics

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Protein & Peptide Letters

Title: Interaction Profiling of T-Cell Epitopes with MHC-Class I Molecules

Volume: 14 Issue: 6

Author(s): Banaja Priyardarshini Dash, Sumanto Mukherjee, V.L. Suhas and Nagasuma Chandra

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Keywords: Epitope prediction, protein-peptide interaction, HLA class-I, vaccine design, structural bioinformatics

Abstract: A key step in rational vaccine development is to understand how antigens are recognized by their receptors. Several crystal structures of MHC/HLA molecules are now available. We report a structural bioinformatics study of peptide- HLA complexes to derive features that generate recognition specificity, useful for guiding the design process.

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Banaja Priyardarshini Dash , Sumanto Mukherjee , V.L. Suhas and Nagasuma Chandra , Interaction Profiling of T-Cell Epitopes with MHC-Class I Molecules, Protein & Peptide Letters 2007; 14 (6) . https://dx.doi.org/10.2174/092986607780989994