X-Ray Structure of HIV-1 Protease Tethered Dimer Complexed to Ritonavir

Amit Das; Dharmaraj Ramachandra Rao; Madhusoodan Vijayacharya Hosur

doi:10.2174/092986607780989930

Abstract

We report here the 2.5Å structure of HIV-1 protease tethered-dimer ritonavir complex. The inhibitor bound in the active site has different conformations in the two orientations. There is only one hydrogen bond between the inhibitor and the enzyme. The conserved flap-water is not found in the present complex.

Keywords: HIV-1 protease, tethered dimmer, inhibitor, X-ray crystallography

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Protein & Peptide Letters

Title: X-Ray Structure of HIV-1 Protease Tethered Dimer Complexed to Ritonavir

Volume: 14 Issue: 6

Author(s): Amit Das, Dharmaraj Ramachandra Rao and Madhusoodan Vijayacharya Hosur

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Keywords: HIV-1 protease, tethered dimmer, inhibitor, X-ray crystallography

Abstract: We report here the 2.5Å structure of HIV-1 protease tethered-dimer ritonavir complex. The inhibitor bound in the active site has different conformations in the two orientations. There is only one hydrogen bond between the inhibitor and the enzyme. The conserved flap-water is not found in the present complex.

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Amit Das , Dharmaraj Ramachandra Rao and Madhusoodan Vijayacharya Hosur , X-Ray Structure of HIV-1 Protease Tethered Dimer Complexed to Ritonavir, Protein & Peptide Letters 2007; 14 (6) . https://dx.doi.org/10.2174/092986607780989930