Distribution of Tripeptides in MHC Binding Peptides

Title: Distribution of Tripeptides in MHC Binding Peptides

Volume: 14 Issue: 6

Author(s): Sharmila Anishetty and Gautam Pennathur

Affiliation:

Keywords: Tripeptides, MHC peptides, Rigid tripeptides, Positional preference, Nonamers, MHCPEP

Abstract: Major Histocompatibility Complex (MHC) molecules are cell surface glycoproteins that are central to the process of immunity. MHC Class I and II molecules differ in their peptide binding specificity. In this study we have analyzed a non redundant set of MHC binding peptides derived from MHCPEP database, in terms of tripeptides and their positional preference. Results indicate that certain tripeptides have a preference to appear at a particular position for a specific allele. Further, the distribution of rigid tripeptides across all binding sequences was also analyzed and their positions were correlated with anchor residue positions.

Cite this article as:

Sharmila Anishetty and Gautam Pennathur , Distribution of Tripeptides in MHC Binding Peptides, Protein & Peptide Letters 2007; 14 (6) . https://dx.doi.org/10.2174/092986607780989895