Targeting CCK Receptors in Human Cancers

Title: Targeting CCK Receptors in Human Cancers

Volume: 7 Issue: 12

Author(s): Jean Claude Reubi

Affiliation:

Keywords: tumor types, gastrointestinal cancers, small cell lung carcinoma, CCK Radioligands, CCK agonists

Abstract: Gut hormone receptors can be over-expressed in several human cancers and represent the basis for receptortargeted tumor imaging and therapy. A promising receptor for such clinical applications is the cholecystokinin receptor. Cholecystokinin receptors are expressed in numerous neuroendocrine tumors, in particular medullary thyroid carcinomas and neuroendocrine gut tumors, as well as in stromal tumors. Moreover, several radiolabeled CCK or gastrin analogs have been developed allowing to detect these tumors and their metastases in patients using in vivo cholecystokinin receptor scintigraphy, proving the feasibility of targeting CCK receptors in human tumors in vivo.

Cite this article as:

Jean Claude Reubi , Targeting CCK Receptors in Human Cancers, Current Topics in Medicinal Chemistry 2007; 7 (12) . https://dx.doi.org/10.2174/156802607780960546