Biological Evaluation of Fluorinated p-Boronophenylalanine Derivatives as a Boron Carrier

Title: Biological Evaluation of Fluorinated p-Boronophenylalanine Derivatives as a Boron Carrier

Volume: 14 Issue: 3

Author(s): Yoshihide Hattori, Kei Kurihara, Hirofumi Kondoh, Tomoyuki Asano, Mitsunori Kirihata, Yoshihiro Yamaguchi and Tateaki Wakamiya

Affiliation:

Keywords: Boron neutron capture therapy (BNCT), fluorinated p-boronophenylalanine, tumor cell killing effect, boron carrier

Abstract: Boron neutron capture therapy (BNCT) and magnetic resonance imaging (MRI) are quite attractive techniques for treatment and diagnosis of cancer, respectively. In order to develop practical materials utilizing both for BNCT and MRI, fluorinated p-boronophenylalanines and their alcohol derivatives had already been designed and synthesized. In the present paper the cytotoxicity, the incorporated amount into cancer cells, and the tumor cell killing effects of these compounds were elucidated to evaluate their usefulness as a boron carrier.

Cite this article as:

Hattori Yoshihide, Kurihara Kei, Kondoh Hirofumi, Asano Tomoyuki, Kirihata Mitsunori, Yamaguchi Yoshihiro and Wakamiya Tateaki, Biological Evaluation of Fluorinated p-Boronophenylalanine Derivatives as a Boron Carrier, Protein & Peptide Letters 2007; 14 (3) . https://dx.doi.org/10.2174/092986607780090856