Boronated DNA-Binding Compounds as Potential Agents for Boron Neutron Capture Therapy

Title: Boronated DNA-Binding Compounds as Potential Agents for Boron Neutron Capture Therapy

Volume: 7 Issue: 3

Author(s): Ellen L. Crossley, Erin J. Ziolkowski, Jeffrey A. Coderre and Louis M. Rendina

Affiliation:

Keywords: Boron neutron capture therapy, boronated agent, carborane, DNA-targeting, boronic acid

Abstract: Boron Neutron Capture Therapy (BNCT) is a binary cancer treatment that exploits the short range particles released from a nuclear fission reaction involving the non-radioactive 10B nucleus and low-energy (thermal) neutrons for the destruction of tumour cells. If boronated agents are targeted towards chromosomal DNA, the efficiency of BNCT is greatly enhanced. This article presents a concise review of DNA-binding compounds that have been functionalised with boron.

Cite this article as:

Crossley L. Ellen, Ziolkowski J. Erin, Coderre A. Jeffrey and Rendina M. Louis, Boronated DNA-Binding Compounds as Potential Agents for Boron Neutron Capture Therapy, Mini-Reviews in Medicinal Chemistry 2007; 7 (3) . https://dx.doi.org/10.2174/138955707780059808